{"id":910,"date":"2026-03-30T18:58:11","date_gmt":"2026-03-30T16:58:11","guid":{"rendered":"https:\/\/epilogy.org\/?p=910"},"modified":"2026-04-01T16:04:23","modified_gmt":"2026-04-01T14:04:23","slug":"antibiotic-use-and-the-persistence-of-biologic-therapies-in-patients-with-psoriasis","status":"publish","type":"post","link":"https:\/\/epilogy.org\/fr\/antibiotic-use-and-the-persistence-of-biologic-therapies-in-patients-with-psoriasis","title":{"rendered":"Utilisation des antibiotiques et persistance des bioth\u00e9rapies chez les patients atteints de psoriasis"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"910\" class=\"elementor elementor-910\">\n\t\t\t\t<div class=\"elementor-element elementor-element-18301b2 e-flex e-con-boxed e-con e-parent\" data-id=\"18301b2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7e8b9f6 elementor-widget elementor-widget-html\" data-id=\"7e8b9f6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<style>\n.epilogy-accordion{\nbackground:#ffffff;\nborder:1px solid #ead3ee;\nborder-radius:8px;\npadding:20px;\nmargin:24px 0;\nfont-size:13px;\ncolor:#54595F;\nline-height:1.7;\nbox-shadow:0 2px 8px rgba(0,0,0,0.04);\n}\n\n.epilogy-accordion details{\nborder-top:1px solid #eee;\npadding:10px 0;\n}\n\n.epilogy-accordion details:first-of-type{\nborder-top:none;\n}\n\n.epilogy-accordion summary{\ncursor:pointer;\nfont-weight:600;\ncolor:#7C2A86;\nfont-size:13px;\nlist-style:none;\nposition:relative;\npadding-left:18px;\n}\n\n.epilogy-accordion summary::before{\ncontent:\"+\";\nposition:absolute;\nleft:0;\ntop:0;\n}\n\n.epilogy-accordion details[open] summary::before{\ncontent:\"\u2013\";\n}\n\n.epilogy-highlight{\nbackground:#FADFFF;\npadding:14px;\nborder-radius:6px;\nmargin-top:18px;\nfont-size:13px;\nborder-left:4px solid #7C2A86;\n}\n\n.epilogy-highlight h3{\nmargin:0 0 6px 0;\ncolor:#7C2A86;\nfont-size:13px;\n}\n\n.epilogy-highlight a{\nfont-size:12px;\nopacity:0.9;\n}\n\n.epilogy-authors{\nmargin-top:20px;\npadding-top:14px;\nborder-top:1px solid #eee;\n}\n\n.epilogy-authors-title{\nfont-weight:600;\ncolor:#7C2A86;\nmargin-bottom:10px;\n}\n\n.epilogy-authors-grid{\ndisplay:grid;\ngrid-template-columns:repeat(3,1fr);\ngap:10px;\ntext-align:center;\n}\n\n.epilogy-authors-grid img{\nwidth:70px;\nheight:70px;\nobject-fit:cover;\nborder-radius:100%;\nfilter:grayscale(100%);\ntransition:all .2s ease;\n}\n\n.epilogy-authors-grid img:hover{\nfilter:grayscale(0%);\ntransform:scale(1.05);\n}\n\n.epilogy-authors-grid span{\ndisplay:block;\nmargin-top:6px;\nfont-size:12px;\n}\n<\/style>\n\n<div class=\"epilogy-accordion\">\n\n<details open>\n<summary>Importance<\/summary>\n<p>\nThe long-term effectiveness of biologic therapies in psoriasis may decline over time. Gut microbiota alterations induced by antibiotics have been proposed as a potential mechanism impairing biologic persistence.\n<\/p>\n<\/details>\n\n<details>\n<summary>Objective<\/summary>\n<p>\nTo evaluate the association between antibiotic exposure and the persistence of biologic therapies in patients with psoriasis.\n<\/p>\n<\/details>\n\n<details>\n<summary>Design, setting, and participants<\/summary>\n<p>\nThis retrospective cohort study used data from the French National Health Insurance database between June 2011 and December 2022. Adults initiating a biologic therapy for psoriasis were included, excluding those with preexisting inflammatory bowel disease at baseline. Data were analyzed from January to September 2024.\n<\/p>\n<\/details>\n\n<details>\n<summary>Exposures<\/summary>\n<p>\nAt baseline, antibiotics exposure was classified as none, 1, or 2 or more dispensations in the 6 months preceding the index date. During follow-up, time-dependent antibiotics exposure was defined as none, 1, or 2 or more antibiotics dispensations in the 6 months prior to each time of follow-up.\n<\/p>\n<\/details>\n\n<details>\n<summary>Main outcomes and measures<\/summary>\n<p>\nThe primary outcome was discontinuation or switch of the initial biologic therapy. Exposure to antibiotics was assessed within 6 months prior to biologic initiation and during follow-up. A weighted Cox marginal structural model was used to estimate adjusted hazard ratios.\n<\/p>\n<\/details>\n\n<details>\n<summary>Results<\/summary>\n<p>\nOf 36 129 included patients, 11 228 (42.0%) were female, 20 192 (55.9%) were male, and the mean (SD) age was 48.4 (15.1) years. A total of 9366 (25.9%) were exposed to antibiotics at baseline and 21 900 (60.6%) during follow-up. The most commonly prescribed antibiotic classes were \u03b2-lactams, macrolides, and fluoroquinolones. Antibiotic exposure was associated with a higher risk of biologic discontinuation (weighted hazard ratio, 1.12; 95% CI, 1.08-1.16), with a stronger effect observed for multiple dispensations (weighted hazard ratio, 1.29; 95% CI, 1.24-1.35), suggesting a dose-response relationship.\n<\/p>\n<\/details>\n\n<details>\n<summary>Conclusion and relevance<\/summary>\n<p>\nIn this cohort study, antibiotic exposure was significantly associated with an increased risk of discontinuation of biologic therapies in psoriasis. These findings support the hypothesis that antibiotics, potentially through gut dysbiosis, may reduce biologic persistence. However, unmeasured confounders limit causal interpretation. Further studies are necessary to validate these findings.\n<\/p>\n<\/details>\n\n<div class=\"epilogy-authors\">\n<div class=\"epilogy-authors-title\">Epilogy team authors<\/div>\n\n<div class=\"epilogy-authors-grid\">\n<div>\n<img decoding=\"async\" src=\"https:\/\/epilogy.org\/wp-content\/uploads\/2026\/03\/Raphael_Ouakrat.png\">\n<span>Rapha\u00ebl Ouakrat<\/span>\n<\/div>\n\n<div>\n<img decoding=\"async\" src=\"https:\/\/epilogy.org\/wp-content\/uploads\/2026\/03\/laietitia-penso-min.png\">\n<span>Laetitia Penso<\/span>\n<\/div>\n\n<div>\n<img decoding=\"async\" src=\"https:\/\/epilogy.org\/wp-content\/uploads\/2026\/03\/emilie-sbidian-min.png\">\n<span>Emilie Sbidian<\/span>\n<\/div>\n<\/div>\n<\/div>\n\n<div class=\"epilogy-highlight\">\n<h3>Antibiotic Use and the Persistence of Biologic Therapies in Patients With Psoriasis<\/h3>\n<p style=\"margin:0;\">\n<a href=\"https:\/\/doi.org\/10.1001\/jamadermatol.2025.4427\" target=\"_blank\">\nhttps:\/\/doi.org\/10.1001\/jamadermatol.2025.4427\n<\/a>\n<\/p>\n<\/div>\n\n<\/div>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a1cb5b9 e-flex e-con-boxed e-con e-parent\" data-id=\"a1cb5b9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ed78d54 elementor-widget elementor-widget-html\" data-id=\"ed78d54\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<script>\ndocument.querySelectorAll('.epilogy-accordion details').forEach((detail) => {\n  detail.addEventListener('toggle', function() {\n    if (this.open) {\n      document.querySelectorAll('.epilogy-accordion details').forEach((other) => {\n        if (other !== this) {\n          other.removeAttribute('open');\n        }\n      });\n    }\n  });\n});\n<\/script>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Importance The long-term effectiveness of biologic therapies in psoriasis may decline over time. Gut microbiota alterations induced by antibiotics have been proposed as a potential mechanism impairing biologic persistence. Objective To evaluate the association between antibiotic exposure and the persistence of biologic therapies in patients with psoriasis. Design, setting, and participants This retrospective cohort study&hellip;&nbsp;<a href=\"https:\/\/epilogy.org\/fr\/antibiotic-use-and-the-persistence-of-biologic-therapies-in-patients-with-psoriasis\" rel=\"bookmark\"><span class=\"screen-reader-text\">Utilisation des antibiotiques et persistance des bioth\u00e9rapies chez les patients atteints de psoriasis<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":1108,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"off","neve_meta_content_width":70,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","neve_meta_reading_time":"","footnotes":""},"categories":[1,18,20],"tags":[],"class_list":["post-910","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-epilogy","category-epinews","category-last-publications"],"_links":{"self":[{"href":"https:\/\/epilogy.org\/fr\/wp-json\/wp\/v2\/posts\/910","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/epilogy.org\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/epilogy.org\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/epilogy.org\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/epilogy.org\/fr\/wp-json\/wp\/v2\/comments?post=910"}],"version-history":[{"count":15,"href":"https:\/\/epilogy.org\/fr\/wp-json\/wp\/v2\/posts\/910\/revisions"}],"predecessor-version":[{"id":1191,"href":"https:\/\/epilogy.org\/fr\/wp-json\/wp\/v2\/posts\/910\/revisions\/1191"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/epilogy.org\/fr\/wp-json\/wp\/v2\/media\/1108"}],"wp:attachment":[{"href":"https:\/\/epilogy.org\/fr\/wp-json\/wp\/v2\/media?parent=910"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/epilogy.org\/fr\/wp-json\/wp\/v2\/categories?post=910"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/epilogy.org\/fr\/wp-json\/wp\/v2\/tags?post=910"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}